Erythema dyschromicum perstans must be distinguished from postinflammatory hyperpigmentation and fixed drug eruption. Erythema dyschromicum perstans edp and ashy dermatosis ad are pigmentary disorders of unknown etiology. Erythema dyschromicum perstans, or ashy dermatosis, is an uncommon, idiopathic, chronic, pigmentary disorder that is characterized by gray, macular, cutaneous discoloration. It is an acquired dermatosis that occurs most frequently in central and south america. A case report successfully treated with tacrolimus. Erythema dyschromicum perstans in a child following an. Erythema dyschromicum perstans ashy dermatosis and related. Some of the welldefined causes of facial melanoses include melasma, riehls melanosis, lichen planus pigmentosus, erythema dyschromicum perstans, and poikiloderma of civatte. Patients have lowtiter antibodies to extranuclear basal cell components. Erythema dyschromicum perstans in an 8yearold indian child. Diseases that approximate the clinical distribution of erythema dyschromicum perstans, such as pityriasis rosea, may result in postinflammatory hyperpigmentation. Ashy dermatosis treatment with clofazimine journal. Background erythema dyschromicum perstans edp or ashy dermatosis is a peculiar, slowly progressive, macular hyperpigmentation, which leaves a permanent discoloration.
Please consult the latest official manual style if you have any questions. Pdf erythema dyscromicum perstans edp or ashy dermatosis is an uncommon pigmentary disorders which. Current understanding of lichen planus pigmentosus, erythema. Sulzberger, who suggested it when examining convits 2 patients in caracas. Ashy dermatosis unilateral erythema dyschromicum perstans abstract ashy dermatosis is a typically asymptomatic disease of unknown origin that causes symmetrical gray spots to appear on the trunk and extremities. Cutaneous pigmentation mimicking ashy dermatosis ad erythema dyschromicum perstans edp has been described with both omeprazole and esomeprazole. Erythema dyschromicum perstans ashy dermatosis is a distinct and somewhat controversial cutaneous eruption that may be best regarded as a form of lichen planus or lichen planus actinicus. Facial pigmentary disorder is a common condition in darkskinned individual which causes significant psychological morbidity to the patients. Erythema dyschronicum perstans with both a macular lesion.
Erythema dyschromicum perstans is a cutaneous pigmentary dermatosis of unknown etiology characterized by asymptomatic macules of an ashygray color 15. The lesions were predominantly located on the extremities and were stationary. It was later called erythema dyschromicum perstans to highlight the erythematous halo around pigmented macules. Auctores journal of orthopaedics and surgical sports. Pdf treatment of skin disease 5th edition by mark g. Kontochristopoulos gj, aroni k, anagnostopoulos g, nakopoulou l, tassopoulos nc 2001 erythema dyschromicum perstans and hepatitis c virus infection. View the article pdf and any associated supplements and figures for a period of 48 hours. Herein, we describe five cases and compare light and electron microscopic findings, direct and indirect immunofluorescence, and dopapositive melanocyte counts between normal and affected skin. Erythema dyschromicum perstans edp is a hypermelanotic disorder of the idiopathic variety characterized by bluegray macules in healthy individuals. Erythema dyschromicum perstans edp is an uncommon disease described as asymptomatic eruption of oval, polycyclic, or irregularly shaped, grayblue hyperpigmented macules on the trunk, arms, face and neck. Erythema dyschromicum perstans edp is a pigmentary disease of unknown etiology in which damage to basal cells is thought to be mediated by adhesion molecules.
Erythema dyschromicum perstans jama dermatology jama. Erythema dyschromicum perstans edp was first described in 1957, and electron microscopic studies were reported in 1969. Jul 18, 2019 in south america, another name, erythema chronicum figuratum melanodermicum, also is used. Erythema dyschromicum perstans and ashy dermatosis the only significant difference between erythema dyschromicum perstans and ashy dermatosis has been the presence of a palpable erythematous border measuring 12 mm in width in the early stages of the former 12,19. The hyperpigmented lesions vary in size from small 1cm lesions to large plaques. Until now, two east asian patients with edp following the lines of blaschko and a japanese patient with edp showing linear and macular involvement have been described in the english.
Recognition of erythema dyschromicum perstans in prepubertal indian children is important for proper diagnosis and to prevent unnecessary investigations. Dermatosis cenicienta pdf new pdf download service. We report 2 cases of ashy dermatosis with unilateral. Download instantly treatment of skin disease comprehensive therapeutic strategies 5th edition by mark g. Eritema discromico perstans, dermatitis cenicienta. Erythema dyschromicum perstans in an infant with positive. In adults, edp has a slow onset and is unlikely to resolve spontaneously. Erythema dyschromicum perstans is a form of acquired dermal macular hyperpigmentation characterised by wellcircumscribed round to oval or irregular patches on the face, neck and trunk that are grey in colour.
Erythema dyschromicum perstans american osteopathic college. Jul 14, 2020 home skin nontumor erythema dyschromicum perstans pending skin nontumor. Erythema dyschromicum perstans edp is a rare disorder characterized by asymptomatic, slowly progressive, ash. Search terms used in this database were as follows. Erythema dyschromicum perstans treated with narrowbandultraviolet b. Notably absent in this pattern are blisters, targetoid lesions, scale, or.
Pdf ultrastructural pathology of erythema dyschromicum. Erythema dyschromicum perstans in an 8yearold indian. Apr 21, 2005 background erythema dyschromicum perstans edp or ashy dermatosis is a peculiar, slowly progressive, macular hyperpigmentation, which leaves a permanent discoloration. The histopathology showed pigment incontinence, accompanied. Diseases that approximate the clinical distribution of erythema dyschromicum perstans, such as pityriasis rosea, may result in. Chlorothalonil exposure among banana farm workers is another possible cause of edp. Erythema dyschromicum perstans showing resolution in an adult.
Erythema dyschromicum perstans edp is an uncommon disease described as asymptomatic eruption of oval, polycyclic, or irregularly shaped, grayblue. Erythema dyschromicum perstans in an infant with positive darier sign. The 2 groups were native field workers of the banana plantations exposed to many pesticides. Erythema dyschromicum perstans also known as ashy dermatosis, and dermatosis cinecienta is an uncommon skin condition with peak age of onset being young adults, but it may also be seen in children or adults of any age. Papillary and deep dermis showed numerous melanophages figure 2. Aug 01, 1989 in other reports lichen planus actinicus or subtropi cum, and lichen pigmentosus, have been men tioned as variants of lichen planus that closely resemble erythema dyschromicum perstans,z 3.
Erythema dyschromicum perstans edp, also known as ashy dermatosis and dermatosis cenicienta, is a benign, uncommon skin condition that presents with generalized ashygray colored macules on the body. Erythema dyschromicum perstans ashy dermatosis and. A perusal of the literature revealed but two cases, to which we add another one. Annular pigmented plaque under the chin actas dermo. Improvement of erythema dyschromicum perstans using a combination of the 1,550nm erbiumdoped fractionated laser and topical tacrolimus ointment. Nonablative 1550 nm fractional laser therapy not effective for erythema dyschromicum perstans and. Topical treatments for melasma and postinflammatory. Erithema dyschromicum perstans italian ministry of health.
Erythema dyschromicum perstans ashy dermatitis entered by. Our dermatology online original article ashy dermatosis. These are the options to access the full texts of the publication piel. The lesions are usually distributed symmetrically on both sun and nonsunexposed areas including the trunk 69. The ashy dermatosis erythema dyschromicum perstans.
Erythema dyschromicum perstans edp is a rare disorder of pigmentation that is most common in hispanic patients. Automatic update in citescore measures average citations received per document published. Erythema dyschromicum perstans edp is a rare disorder characterized by asymptomatic, slowly progressive, ashgray macular pigmentation of the skin, which usually occurs from age 5 years through. These findings were consistent with ashy dermatosis. Pathology outlines erythema dyschromicum perstans pending. Proton pump inhibitorinduced erythema dyschromicum perstans.
The term erythema dyschromicum perstans was coined by venezuelan physician marion sulzberger to highlight the word erythema because an erythematous border is observed in the early lesions and also to suggest the variety and persistence of the dyschromia. Auctores journal of orthopaedics and surgical sports medicine. Converter download video from dailymotion to mp4, mp3, aac, m4a, f4v, or 3gp for free. A 32 year old female developed erythema dyschromicum perstans. Erythema dyschromicum perstans edp primarily affects latin americans but is. Sulzbergers comment, in discussion of another paper, is as follows.
The photos of erythema dyschromicum perstans below are not recommended for people with a weak psyche. It is most commonly seen in women in latin america and asia. Ashy dermatosis, or erythema dyschromicum perstans, is a rare dermatosis of unknown etiology. Erythema is defined as cutaneous diseases that present with large patches of red skin, without overlying changes in the epidermis. Erythema dyschromicum perstans edp can be difficult to diagnose and treat. Pdf immunopathologic study of erythema dyschromicum. Recognition of erythema dyschromicum perstans in prepubertal indian children is important for proper diagnosis and to. Proton pump inhibitors ppis are potent inhibitors of gastric acid secretion by parietal cells in gastric mucosa. Most cases reported to date are of latin american and indian patients. Mar 23, 2021 improvement of erythema dyschromicum perstans using a combination of the 1,550nm erbiumdoped fractionated laser and topical tacrolimus ointment. Cutaneous mastocytosis must be distinguished from ashy dermatitis or erythema dyschromicum perstans, nodular scabies, neurofibromatosis, juvenile english pro pts in pair. We present a case of edp in an adult that cleared significantly after 6 years. The principal differential diagnosis to consider is erythema dyschromicum perstans edp.
Erythema dyschromicum perstans erythema dyschromicum perstans edp is a pigmentary disorder characterized by multiple pigmented macules on the trunk and proximal. The condition has very rarely been reported in prepubertal indian children. It is characterized by disseminated macular lesions of an ashy gray color. Ribociclibinduced erythema dyschromicum perstans ashy dermatosislike pigmentation in a metastatic breast cancer patient. Jun 10, 2015 erythema dyschromicum perstans edp is a rare cutaneous eruption of unknown etiology that often resolves in prepubertal children but is generally thought to persist in adults. Erythema dyschromicum perstans gray to bluebrown lesions inflammatory phase with rim of erythema occasionally seen distribution includes nonsunexposed areas exogenous ochronosis history of hydroquinone application bananashaped, yellowbrown deposits in the dermis. Erythema annulare centrifugum eac, is a descriptive term for a class of skin lesion presenting redness in a ring form anulare that spreads from a center centrifugum. It is a form of acquired dermal macular hyperpigmentation.
Pdf objective erythema dyschromicum perstans edp can be difficult to diagnose and treat. Included in this group are disorders that have a netlike or reticulated pattern of redness. We studied 39 patients with erythema dyschromicum perstans like dermatitis seen at changuinola hospital in panama. Clinical and histological features were suggestive of erythema discromicum perstans. Wolfshohl ja1, geddes er2, stout ab2, friedman pm234. What is the pathophysiology of erythema dyschromicum perstans.
Objective erythema dyschromicum perstans edp can be difficult to diagnose and treat. The first case to be reported in the united states is described. The etiology and clinical course in children is poorly defined. Erythema dyschromicum perstans edp or ashy dermatosis ad is a. The eruption coalesces into confluent patches that may assume oval or polycyclic configurations. Dear editor, erythema dyschromicum perstans edp ashy dermatosis is an idiopathic acquired dermal melanosis characterized by asymptomatic, ash.
Participation is free and the site has a strict confidentiality policy. Erythema dyschromicum perstans edp is a rare cutaneous eruption of unknown etiology that often resolves in prepubertal children but is generally thought to. Erythema dyschromicum perstans jama dermatology jama network. Indian journal of dermatology, venereology and leprology. This report describes the presentation, histopathologic findings, and treatment of edplike pigmentation in the setting of. Later, erythema dyschromicum perstans was called dermatosis ceniciento, meaning ashy dermatosis, because of its ashy bluish gray color. Erythema dyschromicum perstans is a recently described dermatosis that appears to be a distinct and diagnosable entity. The term erythema dyschromicum perstans is credited to marion b. The search date range was selected from january 1, 1970 through december 31, 2018. Erythema dyschromicum perstans edp is a disorder of pigmentation that is characterized by gray or bluebrown macules or patches in individuals with fitzpatrick skin types iiiv chang et al. We wish you a cure and never get sick of this disease. We report an 8yearold east indian boy with erythema dyschromicum perstans. Ashy dermatosis erythema dyschromicum perstans is an asymptomatic eruption of oval, polycyclic or irregularly shaped, greyblue, hyperpigmented macules on. The condition was accompanied by intestinal parasitism, control of which produced remission of the active skin lesions.
Erythema dyschromicum perstans ashy dermatosis jama. Erythema dyschromicum perstans is a distinctive appearing dermatosis belonging to the erythema perstans group. Improvement of erythema dyschromicum perstans using a. Involvement of cell adhesion and activation molecules in the pathogenesis of erythema dyschromicum perstans ashy dermatitis.
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