It is the prototype of cutaneous bcell pseudolymphoma and perhaps the most common variant. Here we report a unique case of an atypical location of lymphocytoma cutis in a 3. A female patient presented with an asymptomatic, indolent dull erythematous, slowly progressive, firm nodular lesion of more than five years duration on right side of face diagnosed histopathologically as lymphocytoma cutis. One patient with jessners lymphocytic infiltrate differed from the other patients by having a marked relative predominance of t suppressorcytotoxic cells.
Lymphocytoma cutis, or benign reactive lymphoid hyperplasia, is an inflammatory skin lesion that mimics clinically and histologically malignant lymphoma. He had no history of trauma to the area, was receiving no medication, and had no significant medical history. Cutaneous lymphoid hyperplasia clh is considered a benign lymphoid reactive process that results from various antigenic stimuli and may have potential for progression to overt lymphoma. Lymphocytoma cutis, also known as cutaneous b cell pseudolymphoma. As a cutaneous pseudolymphoma, clh often mimics lymphoma both clinically and histologically. Inflammatory dermatoses mimicking malignancy pseudolymphoma.
Nov 01, 20 lymphocytoma cutis, or spieglerfendt sarcoid, is classed as one of the pseudolymphonas, 1 referring to inflammatory disorders in which the accumulation of lymphocytes on the skin resemble, clinically and histopathologically, cutaneous lymphomas. Role of the argon laser in treatment of lymphocytoma cutis. A series of five patients successfully treated with cryosurgery avery s. Lymphocytoma cutis was first described by spiegler in 1894. It clinically presents as skincolored to darkred papules, nodules, or infiltrative plaques similar in appearance to cutaneous malignant lymphoma. We detected zinc through scanning electron microscopy from the specimen of case 1 and gold and titanium through transmission electron microscopy from case 2. Lymphocytoma cutis primary care dermatology society uk. Aug 14, 2019 this example of lymphocytoma cutis shows a localized, erythematoustobrown, illdefined plaque. Lymphocytoma cutis lc is a prototypic lesion of cutaneous pseudolymphomas. Pseudolymphoma of the skin is a descriptive term for a group of benign conditions characterized by a lymphocytic. Lymphocytoma cutis, or lymphadenosis benigna cutis labc, has also been considered a cutaneous from the departments of pathology a and dermatology, b womens college hospital, university of toronto, and the arbovirus refer ence service, department of microbiology, university of toronto5 reprint requests. Clinically it is manifested as asymptomatic, indolent, nodular lesions of different sizes varying between 2 and 5 cm, usually solitary, mainly on exposed area of the body like. Aug 01, 2010 lymphocytoma is a benign polyclonal bcell lymphoproliferative process. Pdf on aug 1, 2002, s gissler and others published borrelia lymphocytoma lymphadenosis benigna cutis find, read and cite all the research you need on researchgate.
Lymphocytoma cutis due to pierced earrings watanabe. Atypical location of lymphocytoma cutis in a child, pediatric. Lymphocytoma cutis following excision arthroplasty core. This example of lymphocytoma cutis shows a localized, erythematoustobrown, illdefined plaque. Sustained remission of recalcitrant cutaneous lymphoid hyperplasia. Pillsbury, in philadelphia, with roentgen ray, grenz ray, prednisone, and triamcinolone. Clinical history, physical examination, and serodiagnosis tests are often sufficient to establish diagnosis, but sometimes, histopathologic analysis is needed to exclude malignant cutaneous. One patient diagnosed as lymphocytoma cutis differed from the other patients by having no detectable b cells. Lymphocytoma cutis and chronic infection, british journal.
This redirect is within the scope of wikiproject medicine. In endemic regions, borrelia burgdorferi is the principal causative agent for lc. Here we report a case of lymphocytoma cutis presenting on the face. The clinical differential diagnosis in each variety is difficult and includes numerous infiltrative disorders. Pdf we describe a clinical case involving a 62yearold white male, diagnosed with lymphocytoma cutis spieglerfendt sarcoid in the cephalic. Lymphocytoma cutis of the shoulder, composed of fleshcolored or erythematous nodules in small groups. Cutaneous pseudolymphomas are a group of benign reactive t or b cell lymphoproliferative processes of diverse etiology that simulate cutaneous lymphomas clinically and histologically. It is a process that simulates a cutaneous lymphoma blood cell cancer developing in the skin, but it behaves in a harmless manner. Lymphocytoma cutis induced by cobalt, british journal of.
Cutaneous bcell pseudolymphoma lymphocytoma cutis of the. Philadelphia dermatological society jama dermatology jama. This lesion presented as a solitary red nodule on the chest. Pdf borrelia lymphocytoma lymphadenosis benigna cutis. Apr 29, 2016 lymphocytoma cutis is a subtype of cutaneous pseudolymphoma involving the face, chest, and upper extremities. Lymphadenosis benigna cutis resulting from borrelia infection. Please visit the project page for details or ask questions at wikipedia talk.
Cutaneous pseudolymphomas actas dermosifiliograficas. Lymphocytoma cutis of the shoulder, composed of fleshcolored. Cutaneous lymphoid hyperplasia refers to a groups of benign cutaneous disorders. Localized lymphocytoma cutis, the most common form, may occur in both children and adults and has a short course. There may be isolated lesions or regionalareas of localization.
Borrelial lc occurs most commonly in areas endemic for ixodes ricinus tick in europe, and it is rare in north america. It can be induced by various antigenic stimuli including arthropod bites, vaccination, and drugs among others. Lymphocytoma cutis due to pierced earrings watanabe 2006. Oct 01, 2000 lymphocytoma cutis and chronic infection sir, lymphocytoma cutis is an uncommon benign infiltrative lymphocytic condition of the skin. Lymphocytoma cutis is a rare cutaneous eruption that may possess clinical and histologic features resembling malignant lymphoma. Sep 01, 20 lyme borreliosis is a common infectious disease that can affect myocardial muscle or the central nervous system if not treated at an early stage. It was reported as a case of pseudoleukemic infiltration of the skin. Cutaneous presentation of orbital follicular lymphoma. Summary a case report of solitary lymphocytoma cutis of the nose and its treatment in a 35. Mar 25, 2011 lymphocytoma cutis, also known as cutaneous b cell pseudolymphoma, represents a spectrum of disease that shares similar clinical and histological features and simulates cutaneous lymphoma clinically and histologically. Cutaneous lymphoid hyperplasia clh is a cutaneous pseudolymphoma with a. Altman and stroiid became aware of the association that exists between nethertons syndrome and ilc. Clh lesions may closely resemble lymphoma both clinically and histologically. Lymphocytoma cutis, or spieglerfendt sarcoid, is classed as one of the.
Biopsy is necessary in establishing a definitive diagnosis as lymphocytoma cutis is commonly confused with other cutaneous lesions. Redirect this redirect does not require a rating on the projects quality scale. Cutaneous lymphoid hyperplasia an overview sciencedirect. Atypical location of lymphocytoma cutis in a child amschler. Cutaneous pseudolymphoma cpl refers to a group of benign, reactive processes that mimic cutaneous lymphoma and are associated with a variety of. Lymphadenosis benigna cutis resulting from borrelia. Histologic features help differentiate lymphocytoma cutis from cutaneous malignant lymphoma. This photograph of lymphocytoma cutis caused by an arthropod bite shows an erythematous scaling patch of the scalp with localized secondary alopecia. Pseudolymphoma, cutaneous lymphoid hyperplasia, reactive lymphoid hyperplasia, lymphocytoma cutis. Atypical location of lymphocytoma cutis in a child. Pdf download for progression of cutaneous bcell pseudolymphoma to. Lymphocytoma cutis is the name for a group of skin disorders defined as benign lymphoproliferative reactions that may. Lymphocytoma cutis is a rare pseudolymphoma that has also been known as cutaneous lymphoid hyperplasia or lymphadenosis benigna cutis. Lymphocytoma cutis, a type of pseudolymphoma, is a rare disorder with distinct clinical and histopathological features.
We studied nine cases of cutaneous lymphoproliferative disease that shared a distinct histologic pattern. Lymphocytoma cutis skin lymphoma americorps health. The lesions consisted of redtoviolaceous, single or clustered, deep papules or nodules. We describe a 6yearold boy who developed borrelia burgdorferiassociated lymphocytoma cutis on the ear. We herein report a case of idiopathic lymphocytoma cuffs, showing a typical nodular infiltrate of lymphocytes that formed a follicular germinal center resembling reactive lymph nodes with numerous tingible bodies, and that revealed a polyclonality in the immunoglobulin gene rearrangement. We report a case of lymphocytoma cutis with conjunctival lesions. Indurated plaques and nodules on the face jama dermatology. Lymphocytoma cutis, also known as cutaneous b cell. The differential diagnosis comprises tick bite granulomas as the patient is an outdoorsman, resolving folliculitis, lymphocytoma cutis and lymphoma. Lymphocytoma cutis with conjunctival lesions british.
Lymphocytoma cutis and chronic infection, british journal of. Foreign bodies lodged in the skin can produce a focal allergic or nonallergic foreign body reaction. Editor, lymphocytoma cutis is a benign lymphoid hyperplasia which typically occurs over the head and neck. Cutaneous involvement from primary orbital lymphoma is uncommon. The term cutaneous pseudolymphoma refers to benign reactive lymphoid proliferations in the skin that simulate cutaneous lymphomas. Cutaneous lymphoid hyperplasia refers to a groups of benign cutaneous disorders characterized by collections of lymphocytes, macrophages, and dendritic cells in the skin 725 conditions included in this groups are 725 cutaneous lymphoid hyperplasia with nodular pattern, a condition of the skin characterized by a solitary or localized cluster of asymptomatic erythematous to violaceous. Other names, borrelial lymphocytoma, lymphadenosis be. Rosa wsc, girao rjs, carvalho ims, vargas lmml an bras dermatol 2017. Entzundliche veranderungen des kindlichen genitales stellen haufig eine diagnostische herausforderung dar. Lymphocytoma cutis lc is one of the most common types of cutaneous b cell pseudolymphoma. Lymphocytoma cutis is a rare, chronic, benign cutaneous bcell lymphoproliferative condition usually presenting with redpurple papules, nodules or plaques predominantly on the head and neck. Borrelial lymphocytoma, lymphadenosis benigna cutis, lymphocytoma cutis, pseudolymphoma, pseudolymphoma of spiegler and fendt, sarcoidosis of spiegler and fendt, spieglerfendt lymphoid hyperplasia, spieglerfendt sarcoid. Histology shows superficial and deep, perivascular, lymphoid hyperplasia with rather burntout germinal centres inset. Reevaluation of ichlhyosis and hair shaii abnormalities.
In 1922, when discussing bibersteins2 case, jadassohn commented that his original. Lyme borreliosis is a common infectious disease that can affect myocardial muscle or the central nervous system if not treated at an early stage. Treatment of cutaneous lymphoid hyperplasia with thalidomide. Lymphocytoma cutis is a rare cutaneous eruption that may. We present a case of a 54yearold woman who spontaneously developed lesions of unknown cause consistent with clh. Borrelial lymphocytoma of the breast areola in a 52year old. Physical examination disclosed numerous erythematous, indurated plaques and nodules on the right side of the forehead and the right cheek. Lymphocytoma is a benign polyclonal bcell lymphoproliferative process. What is the pathophysiology of cutaneous pseudolymphoma. Download citation on nov 1, 2000, b chodynicka and others published lymphocytoma cutis. We report a case of lymphocytoma cutis induced by cobalt material. Spieglerfendt sarcoid lymphocytoma cutis, presenting as an asymptomatic, slowly progressive, erythematous macule of the size of a guinea over the left cheek, is presented in a 7yearold girl. Cutaneous pseudolymphoma cpl, lymphocytoma cutis, lymphadenosis benigna cutis, pseudolymphoma of spieglerfendt, cutaneous lymphoid hyperplasia refers to a benign process that may clinically andor histologically mimic lymphoma. Lymphocytoma cutis treated with topical tacrolimus.
Lymphocytoma cutis, also known as cutaneous b cell pseudolymphoma, represents a spectrum of disease that shares similar clinical and histological features and simulates cutaneous lymphoma clinically and histologically. It represents an exaggerated local immune response to diverse stimuli, the most widely described of which are arthropod bites. Two cases of disseminated lymphocytoma cutis are reported. Pdf lymphocytoma cutis, also known as cutaneous b cell pseudolymphoma, represents a spectrum of disease that shares similar clinical and. Lymphocytoma cutis the patient is a 68 yo male who presents with a 1. We report two cases of lymphocytoma cutis caused by pierced earrings, with the results of patch tests and x. Jan 29, 2004 lymphocytoma cutis lc is considered as the stereotypical example of the cutaneous b. The condition began some 15 years ago as an isolated pink nodule on the left arm, gradually progressing to form nodules and irregular halfcircles. It is characterized by a relatively dense, bcell rich lymphoid infiltrate in the dermis. The aetiology is unknown, but it has been reported to be associated with chronic infection,1 and has been treated with antibiotic therapy.
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